Michael M. Morgan
Ph.D. University of California, Los Angeles, 1989
Office: CLS 208G – Vancouver (Regional Campus)
Phone: (360) 546-9726
- Psychology 312: Research Methods in Psychology
- Psychology 372: Introduction to Physiological Psychology
- Psychology 401: Historical Development of Psychology
- Psychology 504: History of Psychology: Theoretical and Scientific Foundations
- Neural Mechanisms of Pain Modulation
Insights into the function of the periaqueductal gray (PAG) can be revealed by examining the behavioral effects evoked from direct application of drugs (e.g., opioids, excitatory amino acids). The running, jumping, and immobility produced by activation of PAG neurons indicate that the function of this structure is the integration of defensive reactions of which pain inhibition is merely one component. Injection of opioids into the PAG inhibits pain by binding to mu-opioid receptors. We currently are examining how administration of different mu-opioid receptor agonists (e.g., morphine, fentanyl, DAMGO) into the PAG vary in the analgesia produced and signaling molecules activated. This type of ligand biased signaling is used to reveal molecular mechanisms underlying antinociception, tolerance, and withdrawal from opioids.
Macey, T. A., Bobeck, E. N., Suchland, K., Morgan, M. M., & Ingram, S. L. (2015). Change in functional selectivity of morphine with the development of antinociceptive tolerance. British Journal of Pharmacology, 172(2):549-61. PMID 24666417.
Morgan, M. M., Reid, R. A., and Saville, K. A. (2014). Functionally selective signaling for morphine and fentanyl antinociception and tolerance mediated by the rat periaqueductal gray. PLoS ONE, 9(12): e11469. PMID 25503060.
Morgan, M. M., Reid, R. A., Stormann, T. M., & Lautermilch, N. J. (2014). Opioid selective antinociception following microinjection into the periaqueductal gray of the rat. J. Pain, 15:1102-1109. PMID 25106089.
Bobeck, E. N., Chen, Q. L., Morgan, M. M., and Ingram, S. L. (2014) Contribution of adenylyl cyclase modulation of pre- and postsynaptic GABA neurotransmission to morphine antinociception and tolerance. Neuropsychopharmacology, 39(9):2142-52. PMID: 24622471.
Mehalick, M. L., Ingram, S. L., Aicher. S. A., & Morgan, M. M. (2013). Chronic inflammatory pain prevents tolerance to the antinociceptive effect of morphine microinjected into the ventrolateral periaqueductal gray of the rat. Journal of Pain, 14:1601-1610. PMID 24161274.
Suckow, S. K., Deichsel, E. L., Ingram, S. L., Morgan, M. M., & Aicher. S. A. (2013). Columnar distribution of catecholaminergic neurons in the ventrolateral periaqueductal gray (vlPAG) and their relationship to efferent pathways. Synapse, 67:94-108. PMID: 23152302
Wilson-Poe, A. R., Pocius, E., Herschbach, M., & Morgan, M. M. (2013). The periaqueductal gray contributes to bidirectional enhancement of antinociception between morphine and cannabinoids. Pharmacology, Biochemistry & Behavior, 103:444-449. PMID: 23063785