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Washington State University
College of Arts and Sciences Department of Psychology

Raymond M. Quock

Honors College Fellow

Ph.D. University of Washington, 1974

Contact Information

Office: Johnson Tower 317
Phone: (509) 335-5529

Classes Taught

  • Psychology 265: Biopsychological Effects of Alcohol and Other Drugs
  • Honors 390: Global Issues in Science.  Section 1: Drug Abuse – A Global Perspective
  • Honors 390: Global Issues in Science.  Section 2: Mental Health – A Global Perspective

Research Interests

  • Pharmacology of Hyperbaric Oxygen (HBO2) Suppression of Chronic Pain and Opiate Withdrawal

HBO₂ therapy has been approved by the FDA for a limited set of clinical indications, although there are clinical reports that HBO₂ therapy appears to be effective in a broader range of conditions, including several examples of chronic pain. We have demonstrated that HBO₂ therapy causes relief of acute pain and gathered convincing evidence that HBO₂ therapy activates antinociceptive pathways in the brain. Further research showed that HBO2 therapy could also relieve neuropathic pain in animal models of chronic pain.  Evidence of an opioid mechanism of HBO2 led to the finding that treatment with HBO2 could   suppress naloxone-precipitated opiate withdrawal in morphine-dependent mice. More recently, we have concluded a clinical study in Spokane. Subjects enrolled in a methadone maintenance program agreed to a 10% reduction in their daily methadone dose so that there was less protection against opioid withdrawal.  HBO2 therapy administered for several days following methadone dose reduction resulted in reduced intensity of opioid withdrawal signs, a prolonged reduction in the methadone dose needed to reduce withdrawal, and improvement in quantity and quality of sleep.  HBO2 therapy may potentially be an innovative approach to the treatment of chronic pain and opioid dependence.

Selected Publications and Presentations

Brewer, A.L., Shirachi, D.Y. and Quock, R.M.  Evaluation of hyperbaric oxygen (HBO2) as a treatment for hyperalgesia associated with naloxone-precipitated withdrawal in morphine-dependent mice.  Experimental Biology 2018, San Diego, CA, April 21-25, 2018

Brewer, A.L., Shirachi, D.Y. and Quock, R.M.  Effect of hyperbaric oxygen (HBO2) on murine nociception using multiple nociception measurements.  17th World Congress on Pain, Boston, MA, September 12–16, 2018

Quock, R.M.  Hyperbaric oxygen treatment of chronic pain and suppression of opioid withdrawal.  8th Annual World Congress of Molecular & Cell Biology, Fukuoka, Japan

Buhler, A.V., S. Tachibana, Y. Zhang and R.M. Quock.  Co-localization of neuronal nitric oxide synthase immunoreactivity with GABAergic and cholinergic, but not noradrenergic and serotonergic neurons, and association with β-endorphinergic and met-enkephalinergic opioidergic fibers in rostral ventromedial medulla and A5 of the mouse.  Brain Research 1698:170-178 (2018)

Brewer, A.L., S. Liu, A.V. Buhler, D.Y. Shirachi and R.M. Quock.  Role of spinal GABA receptors in the acute antinociceptive response of mice to hyperbaric oxygen.  Brain Research 1699:107-116 (2018)

Brewer, A.L. and Quock, R.M.  A time course of the development of hyperalgesia during spontaneous withdrawal in NIH Swiss mice.  American Pain Society, Milwaukee, WI, April 3-6, 2019

Quock, R.M. and Brewer, A.L.  Establishing a time course for spontaneous opioid withdrawal in male and female outbred mice using an abbreviated dependence paradigm.  Experimental Biology 2019, Orlando, FL, April 6-9, 2019

Zhang, Y., A.L. Brewer, J.R. Nelson, P.T. Smith, D.Y. Shirachi and R.M. Quock.  Hyperbaric oxygen produces a nitric oxide synthase-regulated anti-allodynic effect in rats with paclitaxel-induced neuropathic pain.  Brain Research 1711:41-47 (2019)

Brewer, A.L., D.Y. Shirachi, R.M. Quock and R.M. Craft.  Effect of hyperbaric oxygen (HBO2) on chemotherapy-induced neuropathy in male and female rats.  Behavioural Pharmacology (in press)

Quock, R.M.  HBOT in the Treatment of Opioid Dependence.  HBOT 2019, 13th Annual Hyperbaric Medicine Symposium, Charleston, SC, September 27-29, 2019

Brewer, A.L., Shirachi, D.Y., Quock, R.M.  Effect of hyperbaric oxygen (HBO2) on withdrawal-induced hyperalgesia during spontaneous withdrawal in morphine-dependent mice.  Neuroscience 2019, Chicago, IL, October 19-23, 2019

Quock, R.M., Wilson, M., Skeiky, L., Stanek, K., Odom-Maryon, T., Hansen, D., Layton, M.  Sleep improves when hyperbaric oxygen therapy administered before and after methadone dose reduction for adults with opioid use disorder.  Neuroscience 2019, Chicago, IL, October 19-23, 2019


Raymond Quock