Raymond M. Quock
Honors College Fellow
Ph.D. University of Washington, 1974
Office: Johnson Tower 317
Phone: (509) 335-5529
- Psychology 265: Biopsychological Effects of Alcohol and Other Drugs
- Honors 390: Global Issues in Science. Section 1: Drug Abuse – A Global Perspective
- Honors 390: Global Issues in Science. Section 2: Mental Health – A Global Perspective
- Pharmacology of Hyperbaric Oxygen (HBO2) Suppression of Chronic Pain and Opiate Withdrawal
HBO₂ therapy has been approved by the FDA for a limited set of clinical indications, although there are clinical reports that HBO₂ therapy appears to be effective in a broader range of conditions, including several examples of chronic pain. We have demonstrated that HBO₂ therapy causes relief of acute pain and gathered convincing evidence that HBO₂ therapy activates antinociceptive pathways in the brain. Further research showed that HBO2 therapy could also relieve neuropathic pain in animal models of chronic pain. Evidence of an opioid mechanism of HBO2 led to the finding that treatment with HBO2 could suppress naloxone-precipitated opiate withdrawal in morphine-dependent mice. More recently, we have concluded a clinical study in Spokane. Subjects enrolled in a methadone maintenance program agreed to a 10% reduction in their daily methadone dose so that there was less protection against opioid withdrawal. HBO2 therapy administered for several days following methadone dose reduction resulted in reduced intensity of opioid withdrawal signs, a prolonged reduction in the methadone dose needed to reduce withdrawal, and improvement in quantity and quality of sleep. HBO2 therapy may potentially be an innovative approach to the treatment of chronic pain and opioid dependence.
Selected Publications and Presentations
Finlay, M., Wilson, M., Erwin, J.A., Skeiky, L., Hansen, D.A. Layton, M., Quock, R.M. and Van Dongen, H.P.A. Nighttime Sleep and respiration in individuals receiving methadone for medication-assisted treatment for opioid use disorder. Journal of Addictions Nursing, in press.
Wilson, M., Bindler, R.J., Stanek, K., Layton, M.E. and Quock, R.M. Hyperbaric oxygen therapy for pain, opioid withdrawal, and related symptoms: A pilot randomized controlled trial. Pain Management Nursing S1524-9042(22)00090-X. doi: 10.1016/j.pmn.2022.03.001. Online ahead of print Apr 4, 2022.
Wilson, M., Odom-Maryon, T., Stanke, K., Rouse, T., Muriungi, J., Jessie, A., Quock, R.M. and Layton, M. Hyperbaric oxygen to assist adults with opioid use disorder in reducing methadone dose. Journal of Addictions Nursing 33(1):27-36, 2022. doi: 10.1097/JAN.0000000000000447.
Zinsky, A.L., Carrion, S., Michal, J.J., Phelps, M.P., Gartstein, M.A., Quock, R.M., Davis, J.F. and Jiang, Z. Genome-to-phenome research in rats: progress and perspectives. International Journal of Biomedical Science 17(1):119-133, 2021. doi: 10.7150/ijbs.51628.
Wilson, M., Odem-Maryon, T., Stanek, K., Layton, M.E. and Quock, R.M. Pain interference influences hyperbaric oxygen treatment response during opioid dose tapering. American Society for Pain Management Nursing, San Antonio, TX, September 29-October 2, 2021. Pain Management Nursing 22(2):232, 2021.
Wilson, M., Stanek, K., Quock, R.M., Layton, M.E., Delaney, and Bindler, R. Piloting a sham condition in adults with opioid use disorder to test effects of hyperbaric oxygen therapy on pain and withdrawal syndrome. American Academy of Pain Medicine 2021 Virtual Annual Meeting, April 23-25, 2021
Skeiky, L., Hansen, D.A., Layton, M., Quock, R.M., Van Dongen, H. and Wilson, M. Naturalistic measurement of sleep/wake disturbance in adults receiving methadone for medication-assisted treatment of opioid use disorder. Sleep 2021, a joint conference of the American Academy of Sleep Medicine and the Sleep Research Society, June 10-13, 2021. Sleep 44(S2):A305, (2021)
Finlay, M., Wilson, M., Erwin, J.A., Hansen, D.A., Layton, M., Quock, R.M. and Van Dongen, H. Individuals receiving methadone for medication-assisted treatment of opioid use disorder show evidence of respiratory depression. Sleep 2020, a joint conference of the American Academy of Sleep Medicine and the Sleep Research Society, Philadelphia, PA, June 13-17, 2020. Sleep 43(S):A278, (2020)
Erwin, J.A., Wilson, M., Finlay, M., Hansen, D.A., Little-Gott, A., Reynolds, D., Quock, R.M., Layton, M. and Van Dongen, H. Sleep architecture in individuals receiving methadone for medication-assisted treatment of opioid use disorder. Sleep 2020, a joint conference of the American Academy of Sleep Medicine and the Sleep Research Society, Philadelphia, PA, June 13-17, 2020. Sleep 43(S):A394-A395, 2020
Rousch, T., Wilson, M., Odem-Maryon, T., Stanek, K., Muriungi, J., Jesse, A., Quock, R.M. and Layton, M. Hyperbaric oxygen effects on pain and withdrawal symptoms in adults with opioid use disorders. American Academy of Pain Medicine 2020 Annual Meeting, National Harbor, MD, February 26-March 1, 2020.
Brewer, A.L., Shirachi, D.Y., Quock, R.M. and Craft, R.M. Effect of hyperbaric oxygen (HBO2) on chemotherapy-induced neuropathy in male and female rats. Behavioural Pharmacology 31:61-72 (February 2020) doi: 10.1097/FBP.0000000000000497.
Emmanouil, D.E., Klein, E.D., Chen, K., Brewer, A.L., Zhang, Y. and Quock, R.M. Nitrous oxide-induced impairment of spatial working memory requires activation of GABAergic pathways. Current Psychopharmacology 9:68-78 (2020)